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Recurrent Miscarriage

 

It is known that overall 15% of all recognized pregnancies end in miscarriage. Recurrent miscarriage is diagnosed when a woman miscarries 3 consecutive times, before 20 weeks gestation. 

 

What factors make one prone to recurrent miscarriage?

 

  •     Autoimmune diseases: diseases that affect placental function and disturb early implantation. 

  •     Chromosome problems: here, both parents are fine, but when their genes are put together, an unusual gene mismatch occurs that may result in miscarriage.

  •     Genetic predispositions for thrombophilias.

  •     Maternal infections that may be passed onto the fetus.

  •     Polycystic ovarian syndrome (PCO)

  •     Thyroid hormone imbalances.

 

 

What laboratory investigations can be done?

 

  •     Autoimmune tests: ANA, Cardiolipin Antibodies, Lupus

  •     Anti-coagulant and TPO.

  •     Chromosomal testing: parental blood karyotyping  and (fetal miscarriage tissue where applicable).

  •     Tests for thrombophilias: Factor V Leiden, Factor II, MTHFR.

  •     Tests for infections: Rubella, CMV, Hepatitis B and C.

  •     Hormone profile for PCO: free testosterone and LH.

  •     Thyroid testing: TSH, T3, T4 and TPO.

  •     Blood group test for Rh factor compatibility for parents.

 

 

MedLabs’ Suggested Recurrent Miscarriage Panel

 

  • Cardiolipin Antibodies

  • Phospholipid Antibodies

  • ANA/ENA

  • Sperm Antibodies

  • Anti-Thrombin III

  • Lupus Anti-Coagulant

  • Factor V Leiden (PCR)

  • Factor II

  • MTHFR

  • TSH/TPO

  • Protein S Free Antigen

  • Protein C Functional

 

 

Physician consultation is recommended